Medical Weight Loss (Semaglutide & Tirzepatide)
GLP-1 receptor agonists are the most effective FDA-approved weight-loss medications available: semaglutide 2.4 mg (Wegovy) produced ~15% average body-weight loss over 68 weeks in the STEP 1 trial (New England Journal of Medicine, 2021), and tirzepatide 15 mg (Zepbound) up to ~21% over 72 weeks in the SURMOUNT-1 trial (New England Journal of Medicine, 2022). They are indicated by the U.S. Food & Drug Administration (FDA) for adults with a BMI ≥30, or ≥27 with a weight-related condition, alongside diet and exercise.
Medical Weight Loss (Semaglutide & Tirzepatide)
We track 1907 verified clinics offering Medical Weight Loss (Semaglutide & Tirzepatide) across our directory. Across 35 clinics with published pricing, cash-pay Medical Weight Loss programs report a median range around $299-$499/mo. Nationally, brand-name GLP-1 therapy (Wegovy/Zepbound) lists at $1,000–$1,350/mo before insurance, while clinic programs built on compounded versions run $199–$400/mo. Average public Google rating across 1583 rated clinics: 4.7★ from 79,511 reviews.
Updated 2026-08-15. Cost figures are estimates, not quotes. See the full year-one cost breakdown.
Diagnostic Biomarker & Clinical Prerequisite Summary
| Diagnostic Clinical Metric | Standard Protocol / Guideline Prerequisite |
|---|---|
| Typical cost | Brand: ~$1,000–$1,350/month before insurance/savings programs; clinic programs with compounded versions have been widely sold for $199–$400/month (see FDA caution below) |
| Eligibility | FDA criteria: BMI ≥30, or ≥27 with a condition like hypertension, type 2 diabetes, or sleep apnea |
| Trial results | Semaglutide 2.4 mg: ~15% average loss (STEP 1, NEJM 2021); tirzepatide 15 mg: ~21% (SURMOUNT-1, NEJM 2022) |
| Most common side effects | Nausea, vomiting, diarrhea, constipation — worst during dose escalation |
| Key caveat | Weight regain is common after stopping (STEP 1 extension, Lancet 2022); plan for maintenance from day one |
How many clinics offer Medical Weight Loss (Semaglutide & Tirzepatide)?
Our directory currently tracks 1907 verified clinics offering Medical Weight Loss (Semaglutide & Tirzepatide). GLP-1 receptor agonists are the most effective FDA-approved weight-loss medications available: semaglutide 2.4 mg (Wegovy) produced ~15% average body-weight loss over 68 weeks in the STEP 1 trial (New England Journal of Medicine, 2021), and tirzepatide 15 mg (Zepbound) up to ~21% over 72 weeks in the SURMOUNT-1 trial (New England Journal of Medicine, 2022). They are indicated by the U.S. Food & Drug Administration (FDA) for adults with a BMI ≥30, or ≥27 with a weight-related condition, alongside diet and exercise.
How GLP-1 medications work
Semaglutide (a GLP-1 receptor agonist) and tirzepatide (a dual GIP/GLP-1 agonist) mimic gut hormones that regulate appetite and blood sugar. Injected once weekly, they slow stomach emptying and reduce hunger signaling, making a sustained calorie deficit achievable for patients who have struggled with diet alone.
In the landmark STEP 1 trial (New England Journal of Medicine, 2021), adults on semaglutide 2.4 mg lost an average of 14.9% of body weight over 68 weeks versus 2.4% on placebo. In the SURMOUNT-1 trial (New England Journal of Medicine, 2022), tirzepatide produced average losses up to 20.9% at the highest 15 mg dose over 72 weeks — approaching bariatric-surgery efficacy for many participants.
Brand-name vs. compounded — read this before buying
Brand-name Wegovy and Zepbound list at roughly $1,000–$1,350/month before insurance or manufacturer savings programs. Because of that price gap, many med spas and telehealth clinics sold compounded semaglutide or tirzepatide for $199–$400/month.
The U.S. Food & Drug Administration (FDA) has repeatedly issued formal drug safety alerts warning about unapproved GLP-1 products: dosing errors requiring hospitalization, unapproved salt forms (semaglutide sodium/acetate) that are not the studied drug, poor cold-chain handling, and — after national shortages resolved — restrictions on mass-compounding copies of available brand drugs. If a program offers compounded GLP-1s, ask where the pharmacy is licensed, whether it is a state-licensed 503A or FDA-registered 503B facility, and exactly what molecule and dose you are receiving.
Side effects and safety
Gastrointestinal side effects — nausea, vomiting, constipation, diarrhea — are the most common and are usually managed with slow dose escalation. Serious but less common risks include pancreatitis, gallbladder disease, and severe gastroparesis-like symptoms. Both drugs carry an FDA boxed warning regarding thyroid C-cell tumors observed in rodent studies; they are contraindicated in patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia type 2 (MEN 2). In addition, the American Society of Anesthesiologists (ASA) issued clinical guidance recommending that patients withhold weekly GLP-1 agonists prior to elective surgery due to delayed gastric emptying and increased pulmonary aspiration risk under anesthesia.
Rapid weight loss also costs muscle. Quality programs pair the medication with adequate protein intake and resistance training, and monitor body composition — not just scale weight. Expect meaningful weight regain if the medication stops without a maintenance plan; trial extension data (STEP 1 extension, Lancet Diabetes & Endocrinology, 2022) showed participants regained approximately two-thirds of their lost weight within one year of discontinuation.
What a legitimate program includes
- Baseline labs: A1c or fasting glucose, lipids, thyroid, metabolic panel
- A licensed prescriber reviewing your history (thyroid cancer, pancreatitis, gallbladder disease, pregnancy plans)
- Documented medication source — brand pens or a named, licensed compounding pharmacy
- Dose-escalation schedule with check-ins, not a vial and a handshake
- Nutrition guidance emphasizing protein and resistance training to preserve muscle
- A maintenance/off-ramp plan discussed before you start, not after
How much does Medical Weight Loss (Semaglutide & Tirzepatide) cost?
Across 35 clinics with cited published pricing, reported cash prices for Medical Weight Loss median at $299-$499/mo.
Which clinics offer Medical Weight Loss (Semaglutide & Tirzepatide)?
| Clinic | Location | Public Google rating | Transparency |
|---|---|---|---|
| Reset TRT & Weight Loss – Hialeah | Hialeah, FL | 4.9★ (97) | Not yet assessed |
| Reset TRT & Weight Loss – Cape Coral | Cape Coral, FL | 4.2★ (40) | Not yet assessed |
| Palm Beach Weight Loss | West Palm Beach, FL | 4.3★ (70) | Not yet assessed |
| South Florida Weight Loss & Wellness | Pembroke Pines, FL | 4.8★ (101) | Not yet assessed |
| Total Anti-Aging & Wellness | Daytona Beach, FL | 4.8★ (54) | Not yet assessed |
| Dr. V Medical Aesthetics (Pensacola) | Pensacola, FL | 4.1★ (89) | Not yet assessed |
| Reset TRT – Palm Bay | Palm Bay, FL | 4.6★ (90) | Not yet assessed |
| Inspo MedSpa | Coral Springs, FL | 5★ (74) | Not yet assessed |
| Redefyne Skin and Body Revival | Pensacola, FL | 4.5★ (47) | 30/100 — Baseline Transparency |
| Advanced Vitality Group – Hollywood | Hollywood, FL | 4.9★ (50) | Not yet assessed |
What clinical guidelines and risks govern Medical Weight Loss (Semaglutide & Tirzepatide)?
Important: Compounded GLP-1 products are not FDA-approved. The U.S. Food & Drug Administration (FDA) has reported dosing errors, unapproved salt forms, and hospitalizations linked to some compounded versions, and has acted to restrict mass compounding of copies of available brand-name drugs. Verify any pharmacy's licensure before purchasing.
Frequently Asked Questions
How much weight will I lose on semaglutide?
In the pivotal STEP 1 trial (New England Journal of Medicine, 2021), adults averaged 14.9% body-weight loss over 68 weeks at the 2.4 mg dose, with about a third of participants losing 20% or more. Individual results vary with dose tolerance, diet, and activity.
Is tirzepatide better than semaglutide?
Tirzepatide produced greater average weight loss in its SURMOUNT-1 trial (up to 20.9% over 72 weeks) than semaglutide did in STEP 1 (14.9% over 68 weeks), and head-to-head trial data (SURMOUNT-5) also favored tirzepatide. Semaglutide has a longer real-world track record and, for some patients, better insurance coverage. Either is a reasonable first choice — availability and cost usually decide.
How much does medical weight loss cost per month?
Brand-name pens list around $1,000–$1,350/month before insurance or manufacturer savings cards. Clinic programs built on compounded versions have commonly charged $199–$400/month — but see the FDA's warnings about unapproved GLP-1 products before choosing on price alone.
Are compounded semaglutide programs safe?
The FDA has documented dosing errors, unapproved salt forms, and adverse events requiring hospitalization with compounded GLP-1s, and has moved to restrict mass compounding now that brand supply has stabilized. If you use one, verify the pharmacy's license and the exact formulation. Brand products are the safer default when accessible.
What happens when I stop taking it?
Appetite returns and trial extensions (STEP 1 extension, Lancet Diabetes & Endocrinology, 2022) showed patients regain a majority of lost weight within a year without a maintenance strategy. Plan the off-ramp before starting: gradual dose taper, continued resistance training, high protein intake, and possibly a lower maintenance dose.
Who should not take GLP-1 medications?
Anyone with a personal or family history of medullary thyroid carcinoma or MEN 2 syndrome (due to an FDA boxed warning), a history of pancreatitis, or who is pregnant or planning pregnancy. Tell your prescriber about gallbladder disease and any planned surgeries — the American Society of Anesthesiologists (ASA) recommends holding weekly GLP-1s before surgery due to aspiration risk from delayed stomach emptying.
Do I need to diet and exercise on these medications?
Yes — the clinical trials (STEP 1, SURMOUNT-1) that produced 15–21% losses included lifestyle intervention, and resistance training plus adequate protein is what protects your muscle mass while losing fat. The medication makes the deficit sustainable; it doesn't replace the fundamentals.
What diagnostic labs are required for Medical Weight Loss (Semaglutide/Tirzepatide)?
Required labs include HbA1c, Fasting Glucose, Thyroid Panel (TSH, Free T3, Free T4), Renal Function (BUN/Creatinine), and Liver Function Tests (ALT/AST).
Will insurance cover Wegovy or Zepbound?
Coverage varies widely by plan and state. Many commercial plans cover with prior authorization and BMI documentation per FDA criteria; coverage through government programs has been shifting. Clinics in this directory that list 'insurance accepted' will verify benefits before your first dose — ask for that check up front.
Browse all Medical Weight Loss clinics
References & Recognized Medical Board Citations
Directory clinical prerequisites, baseline bloodwork guidelines, and treatment protocols listed on VerifiedAntiAgingClinics.com align with published clinical practice guidelines established by recognized national medical boards and professional societies, including the American Board of Obesity Medicine (ABOM), American Board of Urology (ABU), American Board of Internal Medicine - Endocrinology (ABIM), The Endocrine Society, The Menopause Society, and the American Urological Association (AUA).
- Once-Weekly Semaglutide in Adults with Overweight or Obesity (STEP 1, Wilding et al., 2021) — New England Journal of Medicine
- Tirzepatide Once Weekly for the Treatment of Obesity (SURMOUNT-1, Jastreboff et al., 2022) — New England Journal of Medicine
- FDA Approves New Drug Treatment for Chronic Weight Management, First Since 2014 — U.S. Food & Drug Administration
- FDA's Concerns with Unapproved GLP-1 Drugs Used for Weight Loss — U.S. Food & Drug Administration
Page updated 2026-08-15. Ratings and review counts are aggregated from public Google Business Profiles and are not our own reviews.